Additional Information
| Product Name: | GSDMD Rabbit pAb |
|---|---|
| Catalog No.: | Z5822-100 |
| Also Known As: | DF5L; DFNA5L; FKSG10; GSDMDC1; GSDMD |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human GSDMD. |
| Swiss Prot. #: | P57764 |
| Calculated MW: | 53kDa |
| Detected MW: | 53KDa/23KDa |
| Applications: | WB (1:500 - 1:2,000) IP (1:50 - 1:200) IHC (1:50 - 1:200) IF (1:50 - 1:200) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Katoh M and Katoh M, (2004) Int J Oncol 25, 765-770. 2. Saeki N, et al. (2009) Genes Chromosomes Cancer 48, 261-271. |
Details
GSDMD is a member of the gasdermin-domain containing protein family. The gasdermin family that includes GSDMA, GSDMB, GSMDC, GSDMD, and GSDME have been shown to play a role in inflammation and cell death. It has been reported to have a critical role as a downstream effector of pyroptosis. Pyroptosis is a lytic type of cell death triggered by inflammasomes, multiprotein complexes assembled in response to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) that result in the activation of caspase-1 and subsequent cleavage of pro-inflammatory cytokines IL-1β and IL-18.
