Additional Information
| Product Name: | Cyclin D1 Rabbit pAb |
|---|---|
| Catalog No.: | Z3112-100 |
| Also Known As: | BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; cyclin D1 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide of human Cyclin D1 |
| Swiss Prot. #: | P24385 |
| Calculated MW: | 33kDa |
| Detected MW: | 33kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Motokura T, et al. (1991) Nature 350, 512-515. 2. Lukas J, et al. (1996) Mol Cell Biol 16, 6917-6925. |
Details
Cyclin D1 is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.
