Additional Information
| Product Name: | Cullin 1 Rabbit mAb |
|---|---|
| Catalog No.: | Y5500-100 |
| Also Known As: | CUL1; Cullin 1; cullin-1; MGC149834; MGC149835 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthesized peptide derived from human Cullin 1. |
| Swiss Prot. #: | Q13616 |
| Calculated MW: | 90 kDa |
| Detected MW: | 90 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Kipreos ET, et al. (1996)Cell 85 (6), 829 - 839. 2. Michel JJ and Xiong Y, (1998) Cell Growth Differ 9, 435 - 449. 3. Pan ZQ, et al. (2004) Oncogene 23, 1985 - 1997. |
Details
Cullin 1 is a core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In particular, Cullin 1 has been shown to mediate ubiquitin dependent degradation of p21/Waf1/Cip1, cyclin D and IkappaB-alpha.
