Additional Information
| Product Name: | CSN5 Rabbit pAb |
|---|---|
| Catalog No.: | Y2742-100 |
| Also Known As: | COPS5; CSN5; JAB1; MOV-34; SGN5 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human CSN5. |
| Swiss Prot. #: | Q92905 |
| Calculated MW: | 37 kDa |
| Detected MW: | 37 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IP (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Claret FX, et al. (1996) Nature 383, 453 - 457. 2. Bech - Otschir D, et al. (2001) EMBO J 20, 1630 - 1639. |
Details
CSN5 is a subunit of the COP9 signalosome complex (CSN) that catalyzes deneddylation activity. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ub ligase activity of SCF-type complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.
