Additional Information
| Product Name: | CSN2 Rabbit pAb |
|---|---|
| Catalog No.: | Y2712-20 |
| Also Known As: | COPS2; ALIEN; CSN2; SGN2; TRIP15 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human CSN2. |
| Swiss Prot. #: | P61201 |
| Calculated MW: | 52 kDa |
| Detected MW: | 52 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:100) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Schaefer L, et al. (1999) Genomics 56, 310 - 316. 2. Min KW, et al. (2005) Biochem Biophys Res Commun 334, 867 - 874. |
Details
CSN2 is a subunit of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ub ligase activity of SCF-type complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.
