Additional Information
| Product Name: | BAP1 Rabbit pAb |
|---|---|
| Catalog No.: | Y9012-100 |
| Also Known As: | BAP1; HUCEP-13; UCHL2; hucep-6 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-729 of human BAP1 (NP_004647.1). |
| Swiss Prot. #: | Q92560 |
| Calculated MW: | 80 kDa |
| Detected MW: | 80 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Buchhagen DL, et al. (1994) Int J Cancer 57, 473 - 479. 2. Jensen DE, et al. (1998) Oncogene 16, 1097 - 1112. |
Details
BAP1 is a UCH family member of DUBs. DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. BAP1 belongs to the ubiquitin carboxy-terminal hydrolase (UCH) family of DUBs. BAP1 binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, BAP1 may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics.
