Additional Information
| Product Name: | Adrm1 Rabbit pAb |
|---|---|
| Catalog No.: | Y2422-20 |
| Also Known As: | ADRM1; ARM-1; ARM1; GP110 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 108-407 of human Adrm1. |
| Swiss Prot. #: | Q16186 |
| Calculated MW: | 42 kDa |
| Detected MW: | 42 kDa |
| Applications: | WB (1:500 - 1:4,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Schreiner P, et al. (2008) Nature 453, 548 - 552. 2. Husnjak K, et al. (2008) Nature 453, 481 - 488. |
Details
Adrm1 is one of the ubiquitin receptors on the 26S proteasome that recurit polyubiquitinated proteins. The 26S proteaosme is composed of 33 different proteins and responsible for degrading polyubiquitinated proteins in a ATP hydrolysis-dependent manner. The 19S regulatory particle can bind polyubiqutin chains to recruit substrates, deubiquitinate to recycle ubiquitin, unfold substrate proteins under ATP hydrolysis, and translocate unfolded proteins to the 20S proteasome for hydrolysis.
