Additional Information
| Product Name: | PAC-1 |
|---|---|
| Also Known As: | N/A |
| Catalog No.: | F7130 |
| Size: | 5 mg |
| CAS: | 315183-21-2 |
| Formula: | C23H28N4O2 |
| Molecular Weight: | 392.49 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Putt et al. (2006) Nat.Chem.Biol. 2 543. 2. Peterson et al. (2009) J.Med.Chem. 52 5721. |
Details
PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.
