Additional Information
| Product Name: | ONC201 (TIC10) |
|---|---|
| Also Known As: | CAS# 1616632-77-9 |
| Catalog No.: | F6165-5 |
| Size: | 5 mg |
| Molecular Weight: | 386.49 g/mol |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >98% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | No |
| Shipping Method: | Room temperature shipping |
| References: | 1. Allen J E, et al. (2013) Sci. Transl. Med., 5, 171ra17 2. Kline C, et al. (2016) Sci. Signal ., 9, 18r |
Details
ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.
