Additional Information
| Product Name: | Omaveloxolone (RTA408) |
|---|---|
| Also Known As: | RTA408 |
| Catalog No.: | F5260-5 |
| Size: | 5 mg |
| CAS: | 1474034-05-3 |
| Formula: | C33H44F2N2O3 |
| Molecular Weight: | 554.71 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Abeti R., et al. (2018) Frontiers in Cellular Neuroscien, 12, Article 188 |
Details
Omaveloxolone (RTA408) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities. Omaveloxolone treatment significantly improves mitochondrial function of Friedreich's Ataxia patient-derived cells.
