Additional Information
| Product Name: | Nutlin-3 |
|---|---|
| Also Known As: | N/A |
| Catalog No.: | F5200 |
| Size: | 5 mg |
| CAS: | 675576-98-4 |
| Formula: | C30H30Cl2N4O4 |
| Molecular Weight: | 581.49 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Vassilev LT, et al. (2004). Science 303 (5659): 844–848. 2. Shangary S, et al. (2008). Annu Rev Pharmacol Toxicol. 49: 223–241. |
Details
Nutlin-3 is a potent and selective small chemical compound that binds murine double minutes (MDM2) and blocks the MDM2/p53 interaction, by which nutlin-3 functions to stabilize p53 and induces senescence in cancer cells that express wild type p53.
