Additional Information
| Product Name: | Necrostatin-1 |
|---|---|
| Also Known As: | Cas# 4311-88-0 |
| Catalog No.: | F7101 |
| Size: | 50 mg |
| Molecular Weight: | 259.33 g/mol |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >98% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | (Click image to enlarge) Purity check of Necrostatin-1 by HPLC |
| Shipping Method: | Room temperature shipping |
| References: | Degterev A, et al. (2008) Nat Chem Biol. 4(5):313-21. |
Details
Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.
Images
(Click image to enlarge)
Purity check of Necrostatin-1 by HPLC
Images
(Click image to enlarge)
Purity check of Necrostatin-1 by HPLC
