Additional Information
| Product Name: | MK-2206 dihydrochloride |
|---|---|
| Also Known As: | MK-2206 2HCl, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one |
| Catalog No.: | F6160 |
| Size: | 5 mg |
| CAS: | 1032350-13-2 |
| Formula: | C25H21N5O.2HCl |
| Molecular Weight: | 480.39 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | Yan L., et al. (2009) Abstract Number: DDT01-1. |
Details
MK-2206 dihydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.
Solubility:
> 20 mg/ml in DMSO
Solubility:
> 20 mg/ml in DMSO
