Additional Information
| Product Name: | MCC950 Sodium Salt |
|---|---|
| Also Known As: | CP-456773 Sodium |
| Catalog No.: | F3210-25 |
| Size: | 25 mg |
| CAS: | 256373-96-3 |
| Formula: | C20H23N2O5SNa |
| Molecular Weight: | 426.46 g/mol |
| Form: | Powder |
| Quality Assurance: | >97% by NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Coll R.C. et al., Nat.Medicine, 2015, 21, 248-255. 2. Tapia-Abellan A. et al., Nat. Chem. Biol. 2019, 15, 560-4. |
Details
MCC950 sodium salt is a selective inhibitor of NLRP3 with an IC50 value of 7.5 nM in bone marrow derived macrophages. It binds the NATCH domain of NLRP3 and blocks NLRP3 oligomerization and activation. .
