Additional Information
| Product Name: | LDN-57444 |
|---|---|
| Also Known As: | LDN57444, UCHL1 inhibitor |
| Catalog No.: | F2104-5 |
| Size: | 5 mg |
| CAS: | 668467-91-2 |
| Formula: | C17H11Cl3N2O3 |
| Molecular Weight: | 397.6 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Cartier AE, et al (2009) J. Neuroscience, 29, 7857. 2. Liu Y, et al (2003)Chem. & Biol, 10, 837. |
Details
LDN-57444 is a potent small chemical inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1, IC50 = 0.88 μM). UCHL1 functions to generate free ubiquitin from ubiquitin precursors. Loss of UCH-L1 activity causes apoptosis due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin could increase spine size while decreasing spine density in hippocampal neurons.
Solubility: ~ 10 mg/ml in DMSO
Working Concentration: 5-25 uM
Solubility: ~ 10 mg/ml in DMSO
Working Concentration: 5-25 uM
