Additional Information
| Product Name: | Idarubicin HCl |
|---|---|
| Also Known As: | 4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl |
| Catalog No.: | F8100 |
| Size: | 5 mg |
| Molecular Weight: | 533.95 g/mol |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >99% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | PDF Datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Fukushima T, et al. (1993). Int. J. Hematol. 57: 121-130. 2. Belaud-Rotureau MA, et al. (2000). Leukemia. 14: 1266-1275. 3. Orlandi P, et al. (2005) J Chemother. 17(6): 663-667. 4. Colburn DE, et al. (2004) Hematology. 9(3): 217-221. |
Details
Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin is developed in an attempt to reduce the cardiotoxicity and enhance the therapeutic efficacy of the parent compound. Idarubicin HCl is an inhibitor of Topo II α and an apoptosis inducer.
How to use
Idarubicin HCL was used at 0.1 nM - 10 nM in various cell-based in vitro assays.
Idarubicin HCL was used at 0.1 nM - 10 nM in various cell-based in vitro assays.
