Additional Information
| Product Name: | AZ1 |
|---|---|
| Also Known As: | USP25/USP28 inhibitor AZ1 |
| Catalog No.: | F4125-25 |
| Size: | 25 mg |
| CAS: | 2165322-94-9 |
| Formula: | C17H16BrF4NO2 |
| Molecular Weight: | 422.21 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Wrigley JD., et al (2017) SCS Chem Bio., 15, 3113. |
Details
AZ1 is a selective and non-competitive Inhibitor of both deubiquitinase USP25 and USP28 with IC50s of 0.62 μM and 0.7 μM, respectively, when assayed in vitro using Ub-rhodamine110 as the substrate . AZ1 reduces cell viability of a range of cancer cell lines with an EC50 around 20 μM.
