Additional Information
| Product Name: | 6xHis-Sumo 3 |
|---|---|
| Also Known As: | SMT3A; Smt3B; SMT3H1; SUMO-3 |
| Catalog No.: | E3320 |
| Size: | 500 µg |
| Molecular Weight: | 11.6 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_006936 |
| Image(s): | No |
| Shipping Method: | Dry ice shipping |
| References: | 1. Boddy MN, et al. (1996) Oncogene 13, 971 – 982. 2. Bayer P, et al. (1998) J Mol Biol 280, 275 – 286. 3. Melchior F, (2000) Annu Rev Cell Dev Biol 16, 591 – 626. 4. Praefcke GJK, et al. (2012) Trends Biochem Sci 37(1), 23 – 31. 5. Werner A, et al. (2012) Mol Cell 46(3), 287 – 298. |
Details
SUMO (small Ub-related modifier) is a Ub-like protein. Three types of SUMO are most commonly studied, SUMO 1, SUMO 2, and SUMO 3. SUMO 2 and SUMO 3 are almost identical isoforms and thus share many functions. Like Ub, SUMO can be conjugated to its target proteins as a polymeric chain. However, SUMO 1 forms chains inefficiently as compared to SUMO 2 and SUMO 3. SUMO is conjugated to target proteins by the E1 (SAE1/SAE2), E2 (Ube2I or Ubc9), E3 (RanBP2/Nup358, amongst others). Protein sumoylation is involved in many cellular processes including gene transcription.
