GNE-6776

GNE-6776 is a selective USP7 inhibitor that non-covalently targets USP7 (IC50 value at 1.34 μM) to attenuate ubiquitin binding, thus inhibiting deubiquitinase activity. It induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds including PIM kinase inhibitors.

Additional Information

Product Name: GNE-6776
Also Known As: 6′-amino-4′-ethyl-5′-(4-hydroxyphenyl)-N-methyl-[3,3′-bipyridine]-6-carboxamide, Cas# 2009273-71-4
Catalog No.: F4112-5
Size: 5 mg
Molecular Weight: 348.41 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >98% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): No
Shipping Method: Room temperature shipping
References: 1. Kategaya L, et al. (2017) Nature, 550(7677):534-538.

Details

GNE-6776 is a selective USP7 inhibitor that non-covalently targets USP7 (IC50 value at 1.34 μM) to attenuate ubiquitin binding, thus inhibiting deubiquitinase activity. It induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds including PIM kinase inhibitors.