Additional Information
Product Name: | NEDD4 Rabbit mAb |
---|---|
Catalog No.: | Y5840-100 |
Also Known As: | NEDD4; NEDD4-1; RPF1 |
Size: | 100 µl |
Concentration: | See labels on tube |
Host Species: | Rabbit |
Isotype: | IgG |
Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human NEDD4. |
Swiss Prot. #: | P46934 |
Calculated MW: | 115 kDa |
Detected MW: | 120 kDa |
Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
Purification: | Protein A or G affinity purification |
Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3 |
Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
PDF Data Sheet: | PDF Datasheet, MSDS |
Image(s): | (Click image to enlarge) |
Shipping Method: | Wet ice shipping |
References: | 1. Nagase T, et al. (1995) DNA Res 2, 37 - 43. 2. Harvey KF and Kumar S, (1999) Trends Cell Biol 9, 166 - 169. |
Details
NEDD4 is a HECT domain-containing E3 ubiquitin ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. A family of NEDD4-like proteins have been defined that includes nine members in humans. NEDD4 regulates a large number of membrane proteins, such as ion channels and membrane receptors, via ubiquitination and endocytosis.