Ubiquitin Vinyl Sulfone (Ub-VS)

Ubiquitin Vinyl Sulfone (Ub-VS) is a potent and irreversible inhibitor of UCH, USP and OTU families of deubiquitinating enzymes (DUBs). It forms a covalent linkage with the active site Cys residue of a DUB. Ub-VS can be used to profile DUB and modify DUBs for structural determination.

Additional Information

Product Name: Ubiquitin Vinyl Sulfone (Ub-VS)
Also Known As: Ub-VS
Catalog No.: M1030
Size: 50 µg
Molecular Weight: 8624 Da by MS
Species: Human
Source: Synthetic
Stock: Product in lyophilized powder form.
Concentration: N/A
Quality Assurance: ≥95% by RP-HPLC and SDS-PAGE
Storage: Powder at −20°C; solution at −80°C. Avoid multiple freeze/thaw cycles.
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: N/A
Image(s): See images in PDF Datasheet
Shipping Method: Room temperature shipping
References: 1. Galardy et al., (2005) Methods in Enzymology 399, 120.
2. de Jong et al., (2012) ChemBioChem 13, 2251.

Details

Ubiquitin Vinyl Sulfone (Ub-VS) is a potent and irreversible inhibitor of UCH, USP and OTU families of deubiquitinating enzymes (DUBs). It forms a covalent linkage with the active site Cys residue of a DUB. Ub-VS can be used to profile DUB and modify DUBs for structural determination.