Additional Information
Product Name: | Ubiquitin Vinyl Sulfone (Ub-VS) |
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Also Known As: | Ub-VS |
Catalog No.: | M1030 |
Size: | 50 µg |
Molecular Weight: | 8624 Da by MS |
Species: | Human |
Source: | Synthetic |
Stock: | Product in lyophilized powder form. |
Concentration: | N/A |
Quality Assurance: | ≥95% by RP-HPLC and SDS-PAGE |
Storage: | Powder at −20°C; solution at −80°C. Avoid multiple freeze/thaw cycles. |
PDF Data Sheet: | PDF Datasheet, MSDS |
NCBI RefSeq: | N/A |
Image(s): | See images in PDF Datasheet |
Shipping Method: | Room temperature shipping |
References: | 1. Galardy et al., (2005) Methods in Enzymology 399, 120. 2. de Jong et al., (2012) ChemBioChem 13, 2251. |
Details
Ubiquitin Vinyl Sulfone (Ub-VS) is a potent and irreversible inhibitor of UCH, USP and OTU families of deubiquitinating enzymes (DUBs). It forms a covalent linkage with the active site Cys residue of a DUB. Ub-VS can be used to profile DUB and modify DUBs for structural determination.