GST-hHR23B (Rad23B)

hHR23A and hHR23B are the human homologues of yeast Rad23. Rad23 can interact with the Rpn10 and Rpn1 subunits of the 26S proteasome via its N-terminal Ub-like domain (UBL). Rad23 also contains two Ub-associated domains (UBA), through which it binds polyubiquitinated proteins for proteasomal degradation. In addition, Rad23 can also bind DNA repair factors to regulate nucleotide excision repair from UV damage.

Additional Information

Product Name: GST-hHR23B (Rad23B)
Also Known As: P58; HR23B; HHR23B
Catalog No.: I1111
Size: 100 µg
Molecular Weight: 43.2 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~90% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_002874
Image(s): No
Shipping Method: Dry ice shipping
References: 1. Watkins JF, et al. (1993) Mol Cell Biol 13(12), 7757 – 7765.
2. Chen L, et al. (2002) Mol Cell Biol 22(13), 4902 – 4913.
3. Wade SL, et al. (2010) Transcription 1, 22–26.

Details

hHR23A and hHR23B are the human homologues of yeast Rad23. Rad23 can interact with the Rpn10 and Rpn1 subunits of the 26S proteasome via its N-terminal Ub-like domain (UBL). Rad23 also contains two Ub-associated domains (UBA), through which it binds polyubiquitinated proteins for proteasomal degradation. In addition, Rad23 can also bind DNA repair factors to regulate nucleotide excision repair from UV damage.