
Additional Information
Product Name: | 6xHis-mISG15-GFP |
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Also Known As: | G1P2; IP17; UCRP; IFI15; hUCRP |
Catalog No.: | E2201 |
Size: | 100 µg |
Molecular Weight: | 44.9 kDa |
Species: | Mouse |
Source: | Bacterial recombinant |
Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
Concentration: | See tube label |
Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
PDF Data Sheet: | PDF Datasheet, MSDS |
NCBI RefSeq: | NM_005101 |
Image(s): | No |
Shipping Method: | Dry ice shipping |
References: | 1. D’Cunha J, et al. (1996) Proc Natl Acad Sci USA 93(1), 211 – 215. 2. D’Cunha J, et al. (1996) J Immunol 157(9), 4100 – 4108. 3. Zhang D, et al. (2011) J Interferon Cytokine Res 21 (1), 119 – 130. |
Details
Interferon – stimulated gene 15 (Isg15) is a 15 kDa Ub – like protein. It is linked to proteins in much the same way as Ub, using the E1, E2, E3 cascade. U bE1L and UbcH8 are the specific E1 and E2, respectively, to mediate protein ISGylation. Several E3s have also been found. Isg15 is induced by type I interferons (IFNα/β) and bacterial and viral infections. Studies are still being conducted to discover the biological functions of Isg15.