E-64D

E-64D, ethyl ester of E-64c, is an irreversible and cell permeable inhibitor of lysosomal and cytosolic cysteine proteases. E-64D inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. It also inhibits degradation of autophagic cargo inside autophagolysosomes.

Solubility: > 10 mg/ml in water or DMSO

Working Concentration: 1-10 uM

Additional Information

Product Name: E-64D
Also Known As: E64D, E-64d,
Catalog No.: P1051-25
Size: 25 mg
CAS: 88321-09-9
Formula: C17H30N2O5
Molecular Weight: 342.4 Da
Form: Lyophilized powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. McGowan EB, et al (1989) Biochem. Biophys. Res. Commun. 158, 432.

Details

E-64D, ethyl ester of E-64c, is an irreversible and cell permeable inhibitor of lysosomal and cytosolic cysteine proteases. E-64D inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. It also inhibits degradation of autophagic cargo inside autophagolysosomes.
Solubility: > 10 mg/ml in water or DMSO
Working Concentration: 1-10 uM