WP-1130

WP-1130 is a partial selective inhibitor of DUBs including Usp9x, Usp5, Usp14, UchL1 and Uch37. WP-1130 treatment was found to suppress the Jak-Stat signaling pathway, induce aggresome formation and lead to tumor cell apoptosis.
Typical concentration for cell culture experiments is 1-5µM.

Additional Information

Product Name: WP-1130
Also Known As: Degrasyn; (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide; CAS# 856243-80-6; C19H18BrN3O
Catalog No.: F2120
Size: 5 mg
Molecular Weight: 384.3 Da
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: > 98% (TLC); NMR (Confirms)
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Kapuria V et al. (2010) Cancer Res. 70(22):9265-76.
2. Bartholomeusz GA et al. (2007) Blood. 109(8):3470-8.

Details

WP-1130 is a partial selective inhibitor of DUBs including Usp9x, Usp5, Usp14, UchL1 and Uch37. WP-1130 treatment was found to suppress the Jak-Stat signaling pathway, induce aggresome formation and lead to tumor cell apoptosis. Typical concentration for cell culture experiments is 1-5µM.