VX-765

VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspase-1 and 4. In cultures of peripheral blood mononuclear cells stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1β and IL-18, but had no affect the secretion of other cytokines including IL-α, TNFα, IL-6 and IL-8

Additional Information

Product Name: VX-765
Also Known As: N/A
Catalog No.: F7120
Size: 5 mg
CAS: 273404-37-8
Formula: C24H33ClN4O6
Molecular Weight: 509 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Wannamaker W, et al. (2007) J Pharmacol Exp Ther 2007,321:509-516.
2. Doitsh G, et al. (2014) Nature 2014,505:509-514.

Details

VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspase-1 and 4. In cultures of peripheral blood mononuclear cells stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1β and IL-18, but had no affect the secretion of other cytokines including IL-α, TNFα, IL-6 and IL-8