VE-821

VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to radiation, also sensitizes cancer cells to chemotherapy.

Additional Information

Product Name: VE-821
Also Known As: 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Catalog No.: F8130
Size: 5 mg
CAS: 1232410-49-9
Formula: C18H16N4O3S
Molecular Weight: 368.41 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Reaper PM, et al. (2011) Nat Chem Biol, 7(7), 428-430.
2. Prevo, R, et al. (2012) Cancer Biol Ther, 13(11) 1072-1081.
3. Huntoon, CJ, et al. (2013) Cancer Res, 73(12) 3683-3691.

Details

VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to radiation, also sensitizes cancer cells to chemotherapy.

Solubility:
20 mg/ml in DMSO