Rapamycin

Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.

Additional Information

Product Name: Rapamycin
Also Known As: AY-22989, LCP-Siro, RAPA, Rapamune, Sirolimus, SILA 9268A, Cas# 53123-88-9
Catalog No.: F6130
Size: 10 mg
Molecular Weight: 914.17 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >99% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): (Click image to enlarge)


Purity check of Rapamycin by HPLC

Shipping Method: Room temperature shipping
References: 1. Corradetti MN, et al. (2006) Oncogene. 25(48):6347-60.
2. Foster KG, et al. (2010) J Biol Chem. 285(19):14071-7.
3. Malagelada C, et al. (2010) J Neurosci. 30(3):1166-75.

Details

Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease. Images
(Click image to enlarge)


Purity check of Rapamycin by HPLC