PYR-41

PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Treatment of cells with PYR-41 inhibits overall protein ubiquitination, prevents ubiquitin-mediated proteasomal degradation, and inhibits pathways mediated by the ubiquitin-proteasome. It has also been found that PYR-41 treatment increases protein sumoylation in cells.

Additional Information

Product Name: PYR-41
Also Known As: 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
Catalog No.: F5100
Size: 5 mg
Molecular Weight: 371.3 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: > 98% (TLC); NMR (Confirms)
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): N/A
Shipping Method: Room temperature shipping
References: Yang, Y., et al. (2007) Cancer Res. 67: 9472.

Details

PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Treatment of cells with PYR-41 inhibits overall protein ubiquitination, prevents ubiquitin-mediated proteasomal degradation, and inhibits pathways mediated by the ubiquitin-proteasome. It has also been found that PYR-41 treatment increases protein sumoylation in cells.