Additional Information
| Product Name: | PR-619 |
|---|---|
| Also Known As: | (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate; CAS# 2645-32-1; C7H5N5S2 |
| Catalog No.: | F2111 |
| Size: | 50 mg |
| Molecular Weight: | 223.28 Da |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | ≥ 98% by HPLC |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | PDF Datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Tian X., et al. (2011) Assay Drug Dev Technol. 9(2):165-73. 2. Seiberlich V., et al. (2012) Biochim Biophys Acta. 1823(11):2057-68. |
Details
A cell-permeable pan deubiquitinating enzyme inhibitor that is known to inhibit ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 inhibits many deubiquitinating enzymes in the 5-20µM range. Treating cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.
