PR-619

A cell-permeable pan deubiquitinating enzyme inhibitor that is known to inhibit ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 inhibits many deubiquitinating enzymes in the 5-20µM range. Treating cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.

Additional Information

Product Name: PR-619
Also Known As: (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate; CAS# 2645-32-1; C7H5N5S2
Catalog No.: F2110
Size: 5 mg
Molecular Weight: 223.28 Da
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: ≥ 98% by HPLC
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh.
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Tian X., et al. (2011) Assay Drug Dev Technol. 9(2):165-73.
2. Seiberlich V., et al. (2012) Biochim Biophys Acta. 1823(11):2057-68.

Details

A cell-permeable pan deubiquitinating enzyme inhibitor that is known to inhibit ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 inhibits many deubiquitinating enzymes in the 5-20µM range. Treating cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.