Pifithrin-alpha

Pifithrin-alpha is an inhibitor of p53, reversibly inhibits p53-dependent transactivation of p53-responsive genes and apoptosis. Pifithrin-α (10 μM) enhances cell survival after genotoxic stress such as UV irradiation and treatment with DNA damage compounds including doxorubicin, etopoxide, and paclitaxel.

Additional Information

Product Name: Pifithrin-alpha
Also Known As: Pifithrin-α, Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1)
Catalog No.: F7161
Size: 25 mg
CAS: 63208-82-2
Formula: C16H18N2OS.HBr
Molecular Weight: 367.3 g/mol
Form: Lyophilized powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Komarov, PG, et al. (1999) Science 285, 1733-1737

Details

Pifithrin-alpha is an inhibitor of p53, reversibly inhibits p53-dependent transactivation of p53-responsive genes and apoptosis. Pifithrin-α (10 μM) enhances cell survival after genotoxic stress such as UV irradiation and treatment with DNA damage compounds including doxorubicin, etopoxide, and paclitaxel.

Solubility:
20 mg/ml in DMSO

Working Condition:
10 μM