Pomalidomide (CC-4047)

Pomalidomide is a second generation immunomodulator, and a thalidomide analog. Pomalidomide is a ligand of the E3 ubiquitin ligase Cereblon (CRBN), and it is widely used in PROTAC design for targeting protein substrates to the ubiqitin ligase CUL4/CRBN for ubiquitination, leading to subsequent proteasomal degradation.

Additional Information

Product Name: Pomalidomide (CC-4047)
Also Known As: CC-4047; Actimid
Catalog No.: F5220-50
Size: 50 mg
CAS: 19171-19-8
Formula: C13H11N3O4
Molecular Weight: 273.24 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: FedEx
References: 1. Dimopoulos M., et al. (2007) The New England Journal of Medicine, 357, 2123. 2. Lopez-Girona AEA., et al. (2012)Leukemia, 26, 2326.

Details

Pomalidomide is a second generation immunomodulator, and a thalidomide analog. Pomalidomide is a ligand of the E3 ubiquitin ligase Cereblon (CRBN), and it is widely used in PROTAC design for targeting protein substrates to the ubiqitin ligase CUL4/CRBN for ubiquitination, leading to subsequent proteasomal degradation.