PAC-1

PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.

Additional Information

Product Name: PAC-1
Also Known As: N/A
Catalog No.: F7130
Size: 5 mg
CAS: 315183-21-2
Formula: C23H28N4O2
Molecular Weight: 392.49 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Putt et al. (2006) Nat.Chem.Biol. 2 543.
2. Peterson et al. (2009) J.Med.Chem. 52 5721.

Details

PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.