P5091

P5091 is a cell permeable, selective and potent inhibitor of ubiquitin-specific protease 7 (USP7, IC₅₀ = 4.2 µM) and USP47. P5091(P005091) induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. It inhibits tumor growth in animal models of cancer.

Additional Information

Product Name: P5091
Also Known As: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
Catalog No.: F4110
Size: 5 mg
Molecular Weight: 348.22 Da
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >99% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): (Click image to enlarge)


Purity check of P5091 by HPLC

Shipping Method: Room temperature shipping
References: 1. Jeffrey GM, et al. (2009) IDrugs. 12(12):750–753.
2. Chauhan D, et al. (2012) Cancer Cell 22(3): 345-358.

Details

P5091 is a cell permeable, selective and potent inhibitor of ubiquitin-specific protease 7 (USP7, IC₅₀ = 4.2 µM) and USP47. P5091(P005091) induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. It inhibits tumor growth in animal models of cancer.

How to use
In vitro: P5091 was used at 5-12 µM in various in vitro assays
In vivo: P5091 was administered through IV injection at 10 mg/kg twice weekly for 3 weeks. Images
(Click image to enlarge)


Purity check of P5091 by HPLC