ONC201 (TIC10)

ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.

Additional Information

Product Name: ONC201 (TIC10)
Also Known As: CAS# 1616632-77-9
Catalog No.: F6165-25
Size: 25 mg
Molecular Weight: 386.49 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >98% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
NCBI RefSeq: N/A
Image(s): No
Shipping Method: Room temperature shipping
References: 1. Allen J E, et al. (2013) Sci. Transl. Med., 5, 171ra17
2. Kline C, et al. (2016) Sci. Signal ., 9, 18r

Details

ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.