Omaveloxolone (RTA408)

Omaveloxolone (RTA408) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities. Omaveloxolone treatment significantly improves mitochondrial function of Friedreich's Ataxia patient-derived cells.

Additional Information

Product Name: Omaveloxolone (RTA408)
Also Known As: RTA408
Catalog No.: F5260-5
Size: 5 mg
CAS: 1474034-05-3
Formula: C33H44F2N2O3
Molecular Weight: 554.71 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Abeti R., et al. (2018) Frontiers in Cellular Neuroscien, 12, Article 188

Details

Omaveloxolone (RTA408) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities. Omaveloxolone treatment significantly improves mitochondrial function of Friedreich's Ataxia patient-derived cells.