Additional Information
Product Name: | Omaveloxolone (RTA408) |
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Also Known As: | RTA408 |
Catalog No.: | F5260-25 |
Size: | 25 mg |
CAS: | 1474034-05-3 |
Formula: | C33H44F2N2O3 |
Molecular Weight: | 554.71 g/mol |
Form: | Powder |
Quality Assurance: | >98% by HPLC and NMR |
Source: | Synthetic |
Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
PDF Data Sheet: | Download PDF datasheet, MSDS |
Image(s): | N/A |
Shipping Method: | Room temperature shipping |
References: | 1. Abeti R., et al. (2018) Frontiers in Cellular Neuroscien, 12, Article 188 |
Details
Omaveloxolone (RTA408) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities. Omaveloxolone treatment significantly improves mitochondrial function of Friedreich's Ataxia patient-derived cells.