Nutlin-3

Nutlin-3 is a potent and selective small chemical compound that binds murine double minutes (MDM2) and blocks the MDM2/p53 interaction, by which nutlin-3 functions to stabilize p53 and induces senescence in cancer cells that express wild type p53.

Additional Information

Product Name: Nutlin-3
Also Known As: N/A
Catalog No.: F5200
Size: 5 mg
CAS: 675576-98-4
Formula: C30H30Cl2N4O4
Molecular Weight: 581.49 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Vassilev LT, et al. (2004). Science 303 (5659): 844–848.
2. Shangary S, et al. (2008). Annu Rev Pharmacol Toxicol. 49: 223–241.

Details

Nutlin-3 is a potent and selective small chemical compound that binds murine double minutes (MDM2) and blocks the MDM2/p53 interaction, by which nutlin-3 functions to stabilize p53 and induces senescence in cancer cells that express wild type p53.