Additional Information
Product Name: | Necrostatin-1 |
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Also Known As: | Cas# 4311-88-0 |
Catalog No.: | F7101 |
Size: | 50 mg |
Molecular Weight: | 259.33 g/mol |
Species: | N/A |
Source: | Synthetic |
Stock: | Powder |
Concentration: | N/A |
Quality Assurance: | >98% by HPLC and NMR |
Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
PDF Data Sheet: | Download PDF datasheet, MSDS |
NCBI RefSeq: | N/A |
Image(s): | (Click image to enlarge) Purity check of Necrostatin-1 by HPLC |
Shipping Method: | Room temperature shipping |
References: | Degterev A, et al. (2008) Nat Chem Biol. 4(5):313-21. |
Details
Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.
Images
(Click image to enlarge)
Purity check of Necrostatin-1 by HPLC
Images
(Click image to enlarge)
Purity check of Necrostatin-1 by HPLC