Necrostatin-1

Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.

Additional Information

Product Name: Necrostatin-1
Also Known As: Cas# 4311-88-0
Catalog No.: F7100
Size: 5 mg
Molecular Weight: 259.33 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >98% by HPLC and NMR
Storage: Eligible for room temperature shipping.Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: Download PDF datasheet, MSDS
NCBI RefSeq: N/A
Image(s): (Click image to enlarge)


Purity check of Necrostatin-1 by HPLC

Shipping Method: Room temperature shipping
References: Degterev A, et al. (2008) Nat Chem Biol. 4(5):313-21.

Details

Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.

Images
(Click image to enlarge)


Purity check of Necrostatin-1 by HPLC