MLN4924

MLN4924 is a cell-permeable and potent inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4.7 nM. At 1 - 3 uM, MLN4924 potently inhibits the activities of Cullin-based E3 ubiquitin ligases in cells as neddylation of Cullin proteins is required for activating these ubiquitin ligases.

Additional Information

Product Name: MLN4924
Also Known As: MLN-4924; Pevonedistat
Catalog No.: F5150-5
Size: 5 mg
CAS: 905579-51-3
Formula: C21H25N5O4S
Molecular Weight: 443.52 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Soucy TA., et al. (2009) Nature, 458, 732.
2. Milhollen MA., et al. (2010) Blood116, 1515.

Details

MLN4924 is a cell-permeable and potent inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4.7 nM. At 1 - 3 uM, MLN4924 potently inhibits the activities of Cullin-based E3 ubiquitin ligases in cells as neddylation of Cullin proteins is required for activating these ubiquitin ligases.