MK-2206 dihydrochloride

MK-2206 dihydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.

Additional Information

Product Name: MK-2206 dihydrochloride
Also Known As: MK-2206 2HCl, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
Catalog No.: F6161
Size: 25 mg
CAS: 1032350-13-2
Formula: C25H21N5O.2HCl
Molecular Weight: 480.39 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Yan L., et al. (2009) Abstract Number: DDT01-1.

Details

MK-2206 dihydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.

Solubility:
> 20 mg/ml in DMSO