MCC950 Sodium Salt

MCC950 sodium salt is a selective inhibitor of NLRP3 with an IC50 value of 7.5 nM in bone marrow derived macrophages. It binds the NATCH domain of NLRP3 and blocks NLRP3 oligomerization and activation.

Additional Information

Product Name: MCC950 Sodium Salt
Also Known As: CP-456773 Sodium
Catalog No.: F3210-5
Size: 5 mg
CAS: 256373-96-3
Formula: C20H23N2O5SNa
Molecular Weight: 426.46 g/mol
Form: Powder
Quality Assurance: >97% by NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Coll R.C. et al., Nat.Medicine, 2015, 21, 248-255.
2. Tapia-Abellan A. et al., Nat. Chem. Biol. 2019, 15, 560-4.

Details

MCC950 sodium salt is a selective inhibitor of NLRP3 with an IC50 value of 7.5 nM in bone marrow derived macrophages. It binds the NATCH domain of NLRP3 and blocks NLRP3 oligomerization and activation.