Additional Information
Product Name: | Lenalidomide (CC-5013) |
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Also Known As: | CC-5013; Revlimid |
Catalog No.: | F5210-10 |
Size: | 10 mg |
CAS: | 191732-72-6 |
Formula: | C13H13N3O3 |
Molecular Weight: | 259.26 g/mol |
Form: | Powder |
Quality Assurance: | >98% by HPLC and NMR |
Source: | Synthetic |
Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
PDF Data Sheet: | Download PDF datasheet, MSDS |
Image(s): | N/A |
Shipping Method: | Room temperature shipping |
References: | 1. Soucy TA., et al. (2009) Nature, 458, 732. 2. Milhollen MA., et al. (2010) Blood116, 1515. 1. Dimopoulos M., et al. (2007) The New England Journal of Medicine, 357, 2123. 2. Lopez-Girona AEA., et al. (2012)Leukemia, 26, 2326. |
Details
Lenalidomide, an analogue of thalidomide, is a ligand of the E3 ubiquitin ligase Cereblon (CRBN), and it recurits two lymphoid transcription factors, IKZF1 and IKZF3, to the CRBN-Cullin4 ubiquitin ligase for ubiquitination, leading to their degradation. Lenalidomide exhibits excellent anticancer activity against multiple myeloma.