Lenalidomide (CC-5013)

Lenalidomide, an analogue of thalidomide, is a ligand of the E3 ubiquitin ligase Cereblon (CRBN), and it recurits two lymphoid transcription factors, IKZF1 and IKZF3, to the CRBN-Cullin4 ubiquitin ligase for ubiquitination, leading to their degradation. Lenalidomide exhibits excellent anticancer activity against multiple myeloma.

Additional Information

Product Name: Lenalidomide (CC-5013)
Also Known As: CC-5013; Revlimid
Catalog No.: F5210-50
Size: 50 mg
CAS: 191732-72-6
Formula: C13H13N3O3
Molecular Weight: 259.26 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Soucy TA., et al. (2009) Nature, 458, 732.
2. Milhollen MA., et al. (2010) Blood116, 1515.
1. Dimopoulos M., et al. (2007) The New England Journal of Medicine, 357, 2123. 2. Lopez-Girona AEA., et al. (2012)Leukemia, 26, 2326.

Details

Lenalidomide, an analogue of thalidomide, is a ligand of the E3 ubiquitin ligase Cereblon (CRBN), and it recurits two lymphoid transcription factors, IKZF1 and IKZF3, to the CRBN-Cullin4 ubiquitin ligase for ubiquitination, leading to their degradation. Lenalidomide exhibits excellent anticancer activity against multiple myeloma.