LDN-57444

LDN-57444 is a potent small chemical inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1, IC50 = 0.88 μM). UCHL1 functions to generate free ubiquitin from ubiquitin precursors. Loss of UCH-L1 activity causes apoptosis due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin could increase spine size while decreasing spine density in hippocampal neurons.

Solubility: ~ 10 mg/ml in DMSO

Working Concentration: 5-25 uM

Additional Information

Product Name: LDN-57444
Also Known As: LDN57444, UCHL1 inhibitor
Catalog No.: F2104-25
Size: 25 mg
CAS: 668467-91-2
Formula: C17H11Cl3N2O3
Molecular Weight: 397.6 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Cartier AE, et al (2009) J. Neuroscience, 29, 7857.
2. Liu Y, et al (2003)Chem. & Biol, 10, 837.

Details

LDN-57444 is a potent small chemical inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1, IC50 = 0.88 μM). UCHL1 functions to generate free ubiquitin from ubiquitin precursors. Loss of UCH-L1 activity causes apoptosis due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin could increase spine size while decreasing spine density in hippocampal neurons.

Solubility: ~ 10 mg/ml in DMSO
Working Concentration: 5-25 uM