KU-60019

KU-60019 is a potent ATM kinase inhibitor (IC50 = 6.3 nM) in cell-free assays. Exhibits little to no nonspecific target effects against a panel of 229 protein kinases, including ATR and DNA-PKcs. It is a highly effective radiosensitizer.

Additional Information

Product Name: KU-60019
Also Known As: 2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
Catalog No.: F8121
Size: 25 mg
CAS: 925701-49-1
Formula: C30H33N3O5S
Molecular Weight: 547.67 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Golding SE, et al. (2009) Mol Cancer Ther, 8(10), 2894-2902.

Details

KU-60019 is a potent ATM kinase inhibitor (IC50 = 6.3 nM) in cell-free assays. Exhibits little to no nonspecific target effects against a panel of 229 protein kinases, including ATR and DNA-PKcs. It is a highly effective radiosensitizer.

Solubility:
10 mg/ml in DMSO