Idarubicin HCl

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin is developed in an attempt to reduce the cardiotoxicity and enhance the therapeutic efficacy of the parent compound. Idarubicin HCl is an inhibitor of Topo II α and an apoptosis inducer.

Additional Information

Product Name: Idarubicin HCl
Also Known As: 4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl
Catalog No.: F8101
Size: 25 mg
Molecular Weight: 533.95 Da
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >99% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: PDF Datasheet, MSDS<
NCBI RefSeq: N/A
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Fukushima T, et al. (1993). Int. J. Hematol. 57: 121-130.
2. Belaud-Rotureau MA, et al. (2000). Leukemia. 14: 1266-1275.
3. Orlandi P, et al. (2005) J Chemother. 17(6): 663-667.
4. Colburn DE, et al. (2004) Hematology. 9(3): 217-221.

Details

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin is developed in an attempt to reduce the cardiotoxicity and enhance the therapeutic efficacy of the parent compound. Idarubicin HCl is an inhibitor of Topo II α and an apoptosis inducer.

How to use
Idarubicin HCL was used at 0.1 nM - 10 nM in various cell-based in vitro assays.