Additional Information
| Product Name: | H-151 |
|---|---|
| Also Known As: | H151 |
| Catalog No.: | F3400-5 |
| Size: | 5 mg |
| CAS: | 941987-60-6 |
| Formula: | C17H17N3O |
| Molecular Weight: | 279.3 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Haag SM, et al., Nature, 2018, 559, 269. |
Details
H-151 is a potent and irreversible inhibitor of stimulator of interferon genes (STING). It covalently modifies cysteine 91 of STING, which blocks STING palmitoylation and clustering, events essential for downstream TBK1 activation and type I interferon production during immune responses to pathogenic and self-DNA detection by the cGAS-STING pathway.
